Publications
Selected slide presentations:
Publications by Interleukin Genetics Scientists and Collaborative Research
General Background on IL1 Genetic Variations
1. Chen, H., Wilkins, L.M., Aziz, N., Cannings, C., Wyllie, D.H., Bingle, C., Rogus, J., Beck, J.D., Offenbacher, S., Cork, M.J. et al. (2006) Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet, http://hmg.oxfordjournals.org/cgi/reprint/ddi469?ijkey=mfydE5CAWn7zGLO&keytype=ref.
2. Nicklin, M.J., Barton, J.L., Nguyen, M., FitzGerald, M.G., Duff, G.W. and Kornman, K. (2002) A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics, 79, 718-25.
3. Duff, G.W. (2000) The cytokine network. In F, B. (ed.), Frontiers in Molecular Biology. Oxford University Press, London, Vol. 25, pp. 152-173.
4. Cox, A., Camp, N.J., Nicklin, M.J., di Giovine, F.S. and Duff, G.W. (1998) An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers. Am J Hum Genet, 62, 1180-8.
IL1 genetic variations are associated with increased risk for Cardiovascular Disease
5. Berger, P., McConnell, J.P., Nunn, M., Kornman, K.S., Sorrell, J., Stephenson, K. and Duff, G.W. (2002) C-reactive protein levels are influenced by common IL-1 gene variations. Cytokine, 17, 171-4.
6. Nicklin, M.J., Hughes, D.E., Barton, J.L., Ure, J.M. and Duff, G.W. (2000) Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. J Exp Med, 191, 303-12.
7. Francis, S.E., Camp, N.J., Dewberry, R.M., Gunn, J., Syrris, P., Carter, N.D., Jeffery, S., Kaski, J.C., Cumberland, D.C., Duff, G.W. et al. (1999) Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease. Circulation, 99, 861-6.
8. Berger, P.B., Nunn, M., Stephenson, K., Duff, G.W., Klee, G.G. and McConnell, J.P. (2001) Association between c-reactive protein and polymorphisms in the Interleukin-1 gene cluster and coronary artery disease on angiography. J Amer Coll Cardio, 37, Supplement 2, A286.
IL1 genetic variations are associated with increased risk for Osteoporosis
9. Stone, K.L., van Dijk, S., Tabor, H.K., Lui, L.L., Kahn, A.J., Cauley, J.A., Ensrud, K.E., Harris, E.L., Zmuda, J.M., Sorrell, J.A. et al. (1999) Association between genotypes in the IL-1 gene cluster and osteoporotic fracture risk in elderly women. J Bone Miner Res, 14, S142.
10. Stone, K.L., van Dijk, S., Tabor, H., Cauley, J., Ensrud, K., Harris, E., Zmuda, J., Hochberg, M., Sorrell, J.A., Duff, G.W. et al. (1999) Polymorphisms in the IL-1 gene cluster and risk of osteoporotic fractures in elderly women. Am J Hum Genet, 65, A399.
11. Eastell, R., Hannon, R.A., Blakemore, A.I., Russell, R.G.G. and Duff, G.W. (1998) IL-1 receptor antagonist genotype is associated with low bone mineral density in postmenopausal women. Bone, 23, S375.
12. Eastell, R., Hannon, R.A., Blakemore, A.I.F., Russell, R.G.G. and Duff, G.W. (1998) IL-receptor antagonist as a predictor of bone loss in postmenopausal women. Bone, 23, S375.
13. Herren, L.T., van Dijk, S., Wang, H.Y. and Kornman, K.S. (1998) IL_1 receptor antagonist as a potential new therapeutic agent for osteoporosis: a computer simulation model of bone remodeling and osteoporosis. Bone, 23, S620.
Perilipin gene variations are associated with body weight and weight loss from dieting
14. Qi, L., Corella, D., Sorli, J.V., Portoles, O., Shen, H., Coltell, O., Godoy, D., Greenberg, A.S. and Ordovas, J.M. (2004) Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clin Genet, 66, 299-310.
15. Corella, D., Qi, L., Sorli, J.V., Godoy, D., Portoles, O., Coltell, O., Greenberg, A.S. and Ordovas, J.M. (2005) Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J Clin Endocrinol Metab, 90, 5121-6.
16. Qi, L., Shen, H., Larson, I., Schaefer, E.J., Greenberg, A.S., Tregouet, D.A., Corella, D. and Ordovas, J.M. (2004) Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes Res, 12, 1758-65.
17. Qi, L., Tai, E.S., Tan, C.E., Shen, H., Chew, S.K., Greenberg, A.S., Corella, D. and Ordovas, J.M. (2005) Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J Mol Med, 83, 448-56.
IL1 genetic variations are associated with increased risk for Asthma and Pulmonary Fibrosis
18. Whyte, M., Hubbard, R., Meliconi, R., Whidborne, M., Eaton, V., Bingle, C., Timms, J., Duff, G., Facchini, A., Pacilli, A. et al. (2000) Increased risk of fibrosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphisms. Am J Respir Crit Care Med, 162, 755-8.
IL1 genetic variations are associated with increased risk for complications of Diabetes
19. Blakemore, A.I., Cox, A., Gonzalez, A.M., Maskil, J.K., Hughes, M.E., Wilson, R.M., Ward, J.D. and Duff, G.W. (1996) Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. Hum Genet, 97, 369-74.
IL1 genetic variations are associated with increased risk for Periodontal Disease
20. Feloutzis, A., Lang, N.P., Tonetti, M.S., Burgin, W., Bragger, U., Buser, D., Duff, G.W. and Kornman, K.S. (2003) IL-1 gene polymorphism and smoking as risk factors for peri-implant bone loss in a well-maintained population. Clin Oral Implants Res, 14, 10-7.
21. Kornman, K.S. and Duff, G.W. (2001) Candidate genes as potential links between periodontal and cardiovascular diseases. Ann Periodontol, 6, 48-57.
22. Mark, L.L., Haffajee, A.D., Socransky, S.S., Kent, R.L., Jr., Guerrero, D., Kornman, K., Newman, M. and Stashenko, P. (2000) Effect of the interleukin-1 genotype on monocyte IL-1beta expression in subjects with adult periodontitis. J Periodontal Res, 35, 172-7.
23. Walker, S.J., Van Dyke, T.E., Rich, S., Kornman, K.S., di Giovine, F.S. and Hart, T.C. (2000) Genetic polymorphisms of the IL-1alpha and IL-1beta genes in African-American LJP patients and an African-American control population. J Periodontol, 71, 723-8.
24. Lang, N.P., Tonetti, M.S., Suter, J., Sorrell, J., Duff, G.W. and Kornman, K.S. (2000) Effect of interleukin-1 gene polymorphisms on gingival inflammation assessed by bleeding on probing in a periodontal maintenance population. J Periodontal Res, 35, 102-7.
25. Hart, T.C. and Kornman, K.S. (1997) Genetic factors in the pathogenesis of periodontitis. Periodontol 2000, 14, 202-15.
26. McDevitt, M.J., Wang, H.Y., Knobelman, C., Newman, M.G., di Giovine, F.S., Timms, J., Duff, G.W. and Kornman, K.S. (2000) Interleukin-1 genetic association with periodontitis in clinical practice. J Periodontol, 71, 156-63.
27. Engebretson, S.P., Lamster, I.B., Herrera-Abreu, M., Celenti, R.S., Timms, J.M., Chaudhary, A.G., di Giovine, F.S. and Kornman, K.S. (1999) The influence of interleukin gene polymorphism on expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid. J Periodontol, 70, 567-73.
28. Kornman, K.S. and di Giovine, F.S. (1998) Genetic variations in cytokine expression: a risk factor for severity of adult periodontitis. Ann Periodontol, 3, 327-38.
29. Kornman, K.S., Pankow, J., Offenbacher, S., Beck, J., di Giovine, F. and Duff, G.W. (1999) Interleukin-1 genotypes and the association between periodontitis and cardiovascular disease. J Periodontal Res, 34, 353-7.
30. Salvi, G.E., Lawrence, H.P., Offenbacher, S. and Beck, J.D. (1997) Influence of risk factors on the pathogenesis of periodontitis. Periodontol 2000, 14, 173-201.
31. Kornman, K.S., Crane, A., Wang, H.Y., di Giovine, F.S., Newman, M.G., Pirk, F.W., Wilson, T.G., Jr., Higginbottom, F.L. and Duff, G.W. (1997) The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol, 24, 72-7.
IL1 genetic variations are associated with increased risk for Restenosis
32. Francis, S.E., Camp, N.J., Burton, A.J., Dewberry, R.M., Gunn, J., Stephens-Lloyd, A., Cumberland, D.C., Gershlick, A. and Crossman, D.C. (2001) Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty. Heart, 86, 336-40.
33. Kastrati, A., Koch, W., Berger, P.B., Mehilli, J., Stephenson, K., Neumann, F.J., von Beckerath, N., Bottiger, C., Duff, G.W. and Schomig, A. (2000) Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting. J Am Coll Cardiol, 36, 2168-73.
IL1 genetic variations are associated with increasd risk for Sepsis
34. Read, R.C., Camp, N.J., di Giovine, F.S., Borrow, R., Kaczmarski, E.B., Chaudhary, A.G., Fox, A.J. and Duff, G.W. (2000) An interleukin-1 genotype is associated with fatal outcome of meningococcal disease. J Infect Dis, 182, 1557-60.
IL1 genetic variations are associated with muscle tissue response after exercise
35. Dennis, R.A., Trappe, T.A., Simpson, P., Carroll, C., Huang, B.E., Nagarajan, R., Bearden, E., Gurley, C., Duff, G.W., Evans, W.J. et al. (2004) Interleukin-1 polymorphisms are associated with the inflammatory response in human muscle to acute resistance exercise. J Physiol, 560, 617-26.
Nutritional Genomics
36. Kornman, K.S. (2006) Interleukin-1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of aging. Am J of Clincal Nutrition, 83 (suppl): 475S-483S.
37. Kaput, J., Ordovas, J.M., Ferguson, L., van Ommen, B., Rodriguez, R.L., Allen, L., Ames, B.N., Dawson, K., German, B., Krauss, R. et al. (2005) The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr, 94, 623-32.
38. Kornman, K.S., Martha, P.M. and Duff, G.W. (2004) Genetic variations and inflammation: a practical nutrigenomics opportunity. Nutrition, 20, 44-9.
Practical applications of genetic testing, confidentiality and privacy
39. Reilly, P. (2004) Is it in your genes? : the influence of genes on common disorders and diseases that affect you and your family. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
40. Reilly, P. (2000) Abraham Lincoln's DNA and other adventures in genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
41. Dhanda, R.K. (2002) Guiding Icarus : merging bioethics with corporate interests. John Wiley & Sons, New York.
42. Wertz, D.C., Fanos, J.H. and Reilly, P.R. (1994) Testing healthy children and adolescents: recommendations for avoiding harm. Genetic Resour, 8, 16-20.
43. Reilly, P.R. (2000) Public concern about genetics. Annu Rev Genomics Hum Genet, 1, 485-506.
45. Reilly, P.R. (1993) Public policy and legal issues raised by advances in genetic screening and testing. Suffolk Univ Law Rev, 27, 1327-57.
46. Reilly, P.R. (1991) Carrier screening for cystic fibrosis: a commentary on current legal and social policy issues. Genetic Resour, 6, 65-6.
47. Reilly, P.R. (1998) Introduction: reading the human genome: Gothic tale or happy ending? J Law Med Ethics, 26, 181-3.
48. Reilly, P.R. (2001) The Human Genome Project. Recent genetic advances will have far-reaching implications for Catholic health care. Health Prog, 82, 24-7.
49. Reilly, P.R. (2001) Legal issues in genomic medicine. Nat Med, 7, 268-71.
50. Reilly, P.R. (2000) Ethical and legal issues in genetic testing to predict risk of heart disease. Am Heart J, 140, S6-10.
51. Reilly, P.R. (1999) Efforts to regulate the collection and use of genetic information. Arch Pathol Lab Med, 123, 1066-70.
Genetics and other risk factors for complex diseases
52. Krolewski, A.S., Poznik, G.D., Placha, G., Canani, L., Dunn, J., Walker, W., Smiles, A., Krolewski, B., Fogarty, D.G., Moczulski, D. et al. (2006) A genome-wide linkage scan for genes controlling variation in urinary albumin excretion in type II diabetes. Kidney Int, 69, 129-36.
53. Poznik, G.D., Adamska, K., Xu, X., Krolewski, A.S. and Rogus, J.J. (2006) A novel framework for sib pair linkage analysis. Am J Hum Genet, 78, 222-30.
54. Dahia, P.L., Hao, K., Rogus, J., Colin, C., Pujana, M.A., Ross, K., Magoffin, D., Aronin, N., Cascon, A., Hayashida, C.Y. et al. (2005) Novel pheochromocytoma susceptibility loci identified by integrative genomics. Cancer Res, 65, 9651-8.
55. Ohmura, K., Johnsen, A., Ortiz-Lopez, A., Desany, P., Roy, M., Besse, W., Rogus, J., Bogue, M., Puech, A., Lathrop, M. et al. (2005) Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. Proc Natl Acad Sci U S A, 102, 12489-94.
56. Araki, S., Ng, D.P., Krolewski, B., Wyrwicz, L., Rogus, J.J., Canani, L., Makita, Y., Haneda, M., Warram, J.H. and Krolewski, A.S. (2003) Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus. J Am Soc Nephrol, 14, 2015-24.
57. Rogus, J.J., Warram, J.H. and Krolewski, A.S. (2002) Genetic studies of late diabetic complications: the overlooked importance of diabetes duration before complication onset. Diabetes, 51, 1655-62.
58. Canani, L.H., Ng, D.P., Smiles, A., Rogus, J.J., Warram, J.H. and Krolewski, A.S. (2002) Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetes. Diabetes, 51, 1188-93.
59. Antonellis, A., Rogus, J.J., Canani, L.H., Makita, Y., Pezzolesi, M.G., Nam, M., Ng, D., Moczulski, D., Warram, J.H. and Krolewski, A.S. (2002) A method for developing high-density SNP maps and its application at the type 1 angiotensin II receptor (AGTR1) locus. Genomics, 79, 326-32.
60. Scott, L. and Rogus, J.J. (2000) Using unaffected child trios to test for transmission distortion. Genet Epidemiol, 19, 381-94.
61. Moczulski, D.K., Scott, L., Antonellis, A., Rogus, J.J., Rich, S.S., Warram, J.H. and Krolewski, A.S. (2000) Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus. Diabet Med, 17, 111-8.
62. Rogus, J.J., Cai, T. and Wei, L.J. (1999) Issues in genomic screening: critical values, sample sizes, and the ability to detect linkage. Genet Epidemiol, 17 Suppl 1, S697-701.
63. Niu, T., Rogus, J.J., Chen, C., Wang, B., Yang, J., Fang, Z., Weiss, S.T. and Xu, X. (2000) Familial aggregation of bronchodilator response: a community-based study. Am J Respir Crit Care Med, 162, 1833-7.
64. Xu, X., Yang, J., Rogus, J., Chen, C. and Schork, N. (1999) Mapping of a blood pressure quantitative trait locus to chromosome 15q in a Chinese population. Hum Mol Genet, 8, 2551-5.
65. Niu, T., Xu, X., Cordell, H.J., Rogus, J., Zhou, Y., Fang, Z. and Lindpaintner, K. (1999) Linkage analysis of candidate genes and gene-gene interactions in chinese hypertensive sib pairs. Hypertension, 33, 1332-7.
66. Xu, X., Rogus, J.J., Terwedow, H.A., Yang, J., Wang, Z., Chen, C., Niu, T., Wang, B., Xu, H., Weiss, S. et al. (1999) An extreme-sib-pair genome scan for genes regulating blood pressure. Am J Hum Genet, 64, 1694-701.
67. Niu, T., Yang, J., Wang, B., Chen, W., Wang, Z., Laird, N., Wei, E., Fang, Z., Lindpaintner, K., Rogus, J.J. et al. (1999) Angiotensinogen gene polymorphisms M235T/T174M: no excess transmission to hypertensive Chinese. Hypertension, 33, 698-702.
68. Lunetta, K.L. and Rogus, J.J. (1998) Strategy for mapping minor histocompatibility genes involved in graft-versus-host disease: a novel application of discordant sib pair methodology. Genet Epidemiol, 15, 595-607.